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教授
李晓光

职称职务:教授、博导
办公地点:逸夫馆420
联系电话:010-82339783
E-mail: lxgchina@sina.com
 

一、个人情况简介

李晓光、教授、博士生导师。1984年毕业于白求恩医科大学,1991-1994年,在日本京都大学再生医学科学研究所留学,从事应用材料和工程等方法修复神经系统损伤的研究。开发了用于修复周围神经损伤的人工神经材料等,并在日本《人工脏器》等杂志发表文章。回国后,一直从事应用组织工程学方法修复神经系统损伤的应用研究和机理研究。主攻方向是脊髓损伤的修复、脑损伤的修复和周围神经损伤的修复。

 

课题组在中枢神经组织工程研究方面取得了重要进展。研制的用于修复脊髓损伤的脊髓重建管获得了国家食品药品监督管理局(SFDA)临床试验研究的批准,这是我国同类项目第一个获得国家批准的临床试验项目。

 

课题组主研方向包括:(1)神经发生及分子机制;(2)应用于中枢神经修复的生物材料支架的改良与优化;(3)应用先进的磁共振成像方法对中枢神经系统(脊髓和脑)损伤及修复进行影像学评估及量化;(4)应用运动捕捉系统进行非人灵长类动物脊髓损伤及修复后的运动学测量及评价,脊髓损伤病人术后康复方案设计及康复评价;(5)应用生物支架材料修复中枢神经损伤的内在机理研究。

 

研究特色: 1、用自主研制的生物活性材料,通过改善人体神经组织损伤局部的微环境,诱导自身内源性干细胞的增殖和分化而修复中枢神经系统损伤;2、采用多种方法综合评价截瘫动物行为恢复情况;引入了康复训练的内容;3、以临床应用为目的,以临床疾病为中心设置课题;4、医工结合,多学科交叉。研究结果与国际同类研究相比居于前沿水平。

 

李晓光教授是国家自然科学基金重点项目、国家科技支撑计划和国家国际科技合作专项等国家重大项目的课题负责人。近年来共培养研究生20名,其中一名博士获2011年北京市优秀博士学位论文及2012年全国优秀博士学位论文。

 

近年来,课题组在应用生物活性载体诱导内源性神经干细胞修复脊髓/脑损伤方面取得了突破性的进展。课题组已经申请和授权多项发明专利,并在相关国际专业性等国际一流杂志《美国国家科学院院刊》(PNAS)、《Biomaterials》等发表了多篇论文,并在《Science》专刊发表论文。代表论文见下:

 

Yang ZY, Zhang AF, Duan HM, Zhang S, Hao P, Ye KQ, Sun YE, Li XG. NT3-choitsan elicits robust endogenous neurogenesis to enable functional recovery after spinal cord injury. Proc. Natl. Acad. Sci. U.S.A. 2015, 112, 13354-13359.

 

Duan HM, Ge WH, Zhang AF, Xi Y, Chen ZH, Luo DD, Cheng Y, Fan KS, Horvath S, Sofroniew MV, Cheng LM, Yang ZY, Sun YE, Li XG. Transcriptome analyses reveal molecular mechanisms underlying functional recovery after spinal cord injury. Proc. Natl. Acad. Sci. U.S.A. 2015, 112, 13360-13365.

 

Xiaoguang Li, Zhaoyang Yang, Aifeng Zhang, et al. Repair of thoracic spinal cord injury by chitosan tube implantation in adult rats. Biomaterials, 2009, 30:1121–1132.

 

Xiaoguang Li, Zhaoyang Yang, Aifeng Zhang. The effect of neurotrophin-3/chitosan carriers on the proliferation and differentiation of neural stem cells. Biomaterials, 2009, 30: 4978–4985.

 

Linhong Mo, Zhaoyang Yang, Aifeng Zhang, et al. The repair of the injured adult rat hippocampus with NT-3-chitosan carriers. Biomaterials, 2010, 31: 2184-2192.

 

Zhaoyang Yang, Hongmei Duan, Linhong Mo, et al. The effect of the dosage of NT-3/chitosan carriers on the proliferation and differentiation of neural stem cells. Biomaterials, 2010, 31:4846-4854.

 

 

   李晓光教授是《Biomaterials》、《Tissue Engineering》、《Materials Science and Engineering C》等期刊审稿人,同时也是国家自然科学基金委员会咨询专家。

 

二、承担的科研项目

(一)国家自然科学基金重点项目

    项目名称: 生物材料支架诱导内源性干细胞修复脊髓损伤的机理及临床前研究

    项目批准号: 31130022

    项目负责人:李晓光

    起止年月: 201201月至201612

(二)国家科技支撑计划 

    课题名称: 中枢神经修复材料

    课题编号: 2012BAI17B04

    项目负责人:李晓光

    起止年月: 20121月至201512

(三)国家国际科技合作专项

    项目名称: 脊髓损伤程度瘢痕范围的诊断标准及临床试验的合作研究

    项目批准号: 2014DFA30640

    项目负责人:李晓光

    起止年月: 201404月至20174

 

三、近年发表的文章:

1.       Can Zhao, Jia-Sheng Rao, Xiao-Jiao Pei, Jian-Feng Lei, Zhan-Jing Wang, Zhaoyang Yang, Xiaoguang Li. Longitudinal study on diffusion tensor imaging and diffusion tensor tractography following spinal cord contusion injury in rats. Neuroradiology, 2016. doi:10.1007/s00234-016-1660-7.

2.       Jia-Sheng Rao, Zuxiang Liu, Can Zhao, Rui-Han Wei, Wen Zhao, Zhaoyang Yang, Xiaoguang Li. Longitudinal evaluation of functional connectivity variation of the monkey sensorimotor network induced by spinal cord injury. Acta Physiologica. 2016. doi:10.1111/apha.12645.

3.       Yang ZY, Zhang AF, Duan HM, Zhang S, Hao P, Ye KQ, Sun YE, Li XG. NT3-choitsan elicits robust endogenous neurogenesis to enable functional recovery after spinal cord injury. Proc. Natl. Acad. Sci. U.S.A. 2015, 112, 13354-13359.

4.       Duan HM, Ge WH, Zhang AF, Xi Y, Chen ZH, Luo DD, Cheng Y, Fan KS, Horvath S, Sofroniew MV, Cheng LM, Yang ZY, Sun YE, Li XG. Transcriptome analyses reveal molecular mechanisms underlying functional recovery after spinal cord injury. Proc. Natl. Acad. Sci. U.S.A. 2015, 112, 13360-13365.

5.       Jia-Sheng Rao, Man Xiu Ma, Can Zhao, Zuxiang Liu, Zhaoyang Yang, Xiaoguang Li. Alteration of brain regional homogeneity of monkeys with spinal cord injury: A longitudinal resting-state functional magnetic resonance imaging study. Magnetic Resonance Imaging. 2015, 33(9):1156-1162.

6.       Jia-Sheng Rao, Manxiu Ma, Can Zhao, Ai-Feng Zhang, Zhao-Yang Yang, Zuxiang Liu, Xiao-Guang Li. Fractional amplitude of low-frequency fluctuation changes in monkeys with spinal cord injury-A resting-state fMRI study. Magnetic Resonance Imaging, 2014, 32(5):482-486.(责任作者)

7.       Jia-Sheng Rao, Ma Manxiu, Can Zhao, Yue Xi, Zhao-Yang Yang, Liu Zuxiang, Xiao-Guang Li. Atrophy and Primary Somatosensory Cortical Reorganization after Unilateral Thoracic Spinal Cord Injury: A ongitudinal Functional Magnetic Resonance Imaging Study. Volume 2013, Article ID 753061, 9 pageshttp://dx.doi.org/10.1155/2013/753061.(责任作者)

8.       Jia-Sheng Rao, Can Zhao, Zhao-Yang Yang, Shu-Yu Li, Tao Jiang, Yu-Bo Fana, Xiao-Guang Li. Diffusion tensor tractography of residual fibers in traumatic spinal cord injury: A pilot study. Journal of Neuroradiology, 2013, 40: 181-186.(责任作者)

9.       Yang ZY, Qiao H, Sun ZW, Li XG. Effect of BDNF-plasma-collagen matrix controlled delivery system on the behavior of the adult rats neural stem cells. Journal of biomedical materials research, 2013,101(2):599-606.(责任作者)

10.    YANG ZhaoYang, QIAO Hui, LI XiaoGuang. Effects of the CNTF-collagen gel-controlled delivery system on rat neural stem/progenitor cells behavior. SCIENCE CHINA, 2010,53(4): 504-510.(责任作者)

11.    YANG ZhaoYang, MO LinHong, DUAN HongMei, Li XiaoGuang. Effects of chitosan/collagen substrates on the behavior of rat neural stem cells. SCIENCE CHINA, 2010,53(2): 215–222.(责任作者)

12.    Zhaoyang Yang Hongmei Duan Linhong Mo,Hui Qiao Xiaoguang Li The effect of the dosage of NT-3/chitosan carriers on the proliferation and differentiation of neural stem cells. Biomaterials 31 (2010) 4846–4854 (责任作者)

13.  Linhong Mo, Zhaoyang Yang, Aifeng Zhang ,Xiaoguang Li . The repair of the injured adult rat hippocampus with NT-3-chitosan carriers Biomaterials. Biomaterials 31 (2010) 2184–2192(责任作者)

14.  Xiaoguang Li, Zhaoyang Yang ,Aifeng Zhang. The effect of rotrophin-3/chitosan carriers on the proliferation and differentiation of neural stem cells. Biomaterials 30 (2009) 4978–4985(任作者)

 15.  Xiaoguang Li, Zhaoyang Yang, Aifeng Zhang , Tailing Wang , Weichang Chen. Repair of thoracic spinal cord injury by chitosan tube implantation in adult rats. Biomaterials 30(2009)1121-1132(责任作)